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Job: Associate Scientist/Scientist, AAV Research, BridgeBio Gene Therapy Inc., Raleigh, NC

General Information


Job title:
Associate Scientist/Scientist, AAV Research
Job location:
Raleigh, NC  27607 United States
Requisition code:
Date posted:
11/19/2021
Compensation:
• Excellent compensation & benefits package (Base, Performance Bonus, Stock, RSU programs)
• Flexible PTO
• A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
• Work with the most productive groups of R&D operators in the industry
• Partnerships with leading institutions
• Commitment to Diversity & Inclusion
Job category:
Research and Development
Employment type:
Full time

Job Description


About BridgeBio

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Who You Are:
The Associate Scientist/Scientist AAV Research will be responsible for all technical laboratory activities to support Bridgebio’s Gene Therapy (BBGT) delivery platform development. This role is a hands-on, laboratory-based position in our Raleigh, NC laboratory and reports to the Senior Scientist AAV Research. The Associate Scientist/Scientist AAV Research closely collaborates with R&D and CMC team members to develop and evaluate novel strategies to generate improved recombinant AAV particles.

Responsibilities:
• Perform in vitro experiments, including planning, execution, data acquisition, analysis, and interpretation, as well as troubleshooting
• Support the development of analytical assays
• Ensure that information is accurately recorded
• Handle and test animal samples and AAV materials
• Assist in small-scale vector production and purification
• Maintain sample inventory
• Prepare presentation materials and report data at internal meetings
• Interface closely with other team members to ensure on-time completion of goals

Job Requirements


• BS/MS/Ph.D. in virology, cell biology, biochemistry, or related field with 3+ years of experience
• Biotechnology or pharmaceutical industry experience is preferred
• Cell culture experience, including transfection and transduction techniques using Adeno-Associated Virus
• Competence in molecular biology techniques, including DNA/RNA isolation procedures, cloning, and detection assays (ddPCR, qPCR)
• Experience in virus production and purification is desirable
• Familiarity with methods to assess protein expression (Western blot, ELISA, flow cytometry) is desirable
• Attention to detail, capability to interpret scientific data, strong problem-solving skills, thorough documentation practice
• A team player with strong verbal and written communication skills
• A healthy level of self-confidence paired with receptiveness to feedback
• A good listener with a positive attitude who strives to foster a culture of innovation
(Job number: 4052849)
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