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Job: Research Associate, Immunology (Cell-Based Assays), AskBio, Durham, NC

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General Information

Job title:
Research Associate, Immunology (Cell-Based Assays)
Job location:
Durham, NC  27709 United States
Requisition code:
Date posted:
Job category:
Clinical Research
Employment type:
Full time

Job Description

About AskBio
Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at

Position Overview
The Research Associate, Immunology (Cell-Based Assays), reporting to the Sr. Scientist, Exploratory Immunology, will be one of the key laboratory members who will have an opportunity to learn and contribute to the development of immunology cell-based assays in support of our gene therapy programs. This is an excellent opportunity for a candidate who is looking to build-up on his/her experience in basic Cell Biology and Immunology lab skills by being involved in planning and execution of pre-clinical studies and the assessment of clinical samples supporting multiple clinical programs.

We are excited about our next Research Associate, Immunology (Cell-Based Assays) to join the AskBio team!

- Execute cell-based immunogenicity assays, including ELISPOT/Fluorospot, viral transduction and reporter assays, or single/multiplex biomarker assays under the guidance of a manager.
- Maintain a laboratory notebook or binder with worksheets recording details of performed experiments according to good documentation practices.
- Maintain inventories and/or place orders of reagents and materials needed for the assigned projects for timely execution of related lab work.
- Perform data analysis and interpret the results accurately.
- Contribute to drafting the reports and presentations for technical discussions and/or investigations with internal and external stakeholders.

Job Requirements

Required Education & Experience
- MS degree with 1-6 years of experience, or a BS/BA degree with 3 or more years of experience in Immunology, Biology, Biochemistry, Biotechnology, Virology or related field in industry, academia, or combination of both.
- Basic lab skills such as adhering to biosafety and chemical use guidelines (training provided) and making reagents at desired dilutions or concentrations.
- Demonstrated experience with mammalian cell culture, handling of primary cells (PBMCs), cell-culture based immune assays including at least one of these techniques: ELISPOT, FluoroSPOT, Flow cytometry/Proliferation assays, performing cell-culture based analytical assays such as ELISA, Meso Scale Diagnostic/Luminex, or western blot and magnetic enrichment of immune cell subsets

Preferred Experience & Skills
- Knowledge of GxP industry practices for the development, qualification/validation of immunogenicity assays
- Experience with electronic lab notebooks, statistical software (Graphpad, JMP) or flow cytometric analysis software such as FCS Express or FlowJo
- Basic office skills using a PC and working with MS office tools (Word, Excel and PowerPoint).
- Self-motivated, organized, individual capable of working independently and as a contributor to a team.
- Strong verbal and written communication skills.
- Excellent interpersonal skills with the ability to interact effectively with teams, internally and externally.
(Job number: 4051898)
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