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Job: Analytical Development Scientist I, Shattuck Labs, Durham, NC

General Information


Job title:
Analytical Development Scientist I
Job location:
Durham, NC  27703 United States
Requisition code:
Date posted:
10/15/2021
Compensation:
Job category:
Manufacturing and Production
Employment type:
Full time

Job Description


About Us
Shattuck Labs, Inc. (NASDAQ: STTK) is a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease, with three ongoing Phase 1 clinical trials. Compounds derived from Shattuck’s proprietary Agonist Redirected Checkpoint, ARC®, platform simultaneously inhibit checkpoint molecules and activate costimulatory molecules within a single therapeutic. The company’s SL-172154 (SIRPa-Fc-CD40L) program, which is designed to block the CD47/SIRPa checkpoint interaction and simultaneously agonize the CD40 pathway, is being evaluated in two Phase 1 trials. A second product candidate, SL-279252 (PD1-Fc-OX40L), is being evaluated in a Phase 1 trial in solid tumors or lymphomas. Additionally, the company is advancing a proprietary Gamma Delta T Cell Engager, GADLEN™, platform, which is designed to bridge gamma delta T cells to tumor antigens for the treatment of patients with cancer. Shattuck has offices in both Austin, Texas and Durham, North Carolina. For more information, please visit: www.ShattuckLabs.com.

About the Position
As a Scientist I in Analytical Development, you will be a member of a growing team with talented scientists. This team is responsible for analytical method development and product characterization in support of process development for the clinical manufacturing of ARC and GADLEN programs. Responsibilities will include analytical method development, sample analysis, data analysis, authoring and reviewing technical reports, identifying new technologies to better support process development, supporting technology transfer into Q.C., generate documents for internal and external analytical support for manufacturing, and CMC sections of regulatory filings. Routine interactions with the cell line development, upstream process development, downstream process development, research, quality, and regulatory groups at Shattuck is a must. The ideal candidate is also well versed in GxP lab practices.
The Scientist I in Analytical Development will be actively involved in working with the Technology operations leadership to develop strategic planning for development of platform methods for the ARC and GADLEN programs.

Job Requirements


Required Qualifications
We are looking for professionals with these required skills to achieve our goals:
• Ph.D. in Chemical/Biochemical Engineering or related Biological Sciences
-or-
• B.S./M.S. in in Chemical/Biochemical Engineering or related Biological Sciences with >3-5 years of experience in the Pharmaceutical/Biotech industry in a process development setting for biopharmaceuticals
• Broad experience in use of analytical instrumentation (plate readers, HPLCs, capillary instruments)
• Experience in analytical assays (CGE, SDS-PAGE, HPLC, UPLC, Octet, etc.)
• Demonstrated ability to work collaboratively in a lab environment
If you have the following characteristics, it would be a plus:
• Working knowledge of ICH/USP guidelines
• Knowledge of Analytical Method Development, Qualification, and Validation
• Excellent written and communication skills
• Experience in data analysis
• Experience in authoring technical reports
• Strong desire to work at the bench
• Working knowledge of cGMP manufacturing processes for biopharmaceuticals
• In-depth knowledge of process development phases
• Working knowledge of Empower or other CDS
• Experiencing in designing assays using QbD principles
(Job number: 4051653)
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