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Job: Scientist, Shattuck Labs, Durham, NC

General Information

Job title:
Job location:
Durham, NC  27701 United States
Requisition code:
Date posted:
Job category:
Research and Development
Employment type:
Full time

Job Description

About Shattuck Labs
Shattuck Labs, Inc. (NASDAQ: STTK) is a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease, with three ongoing Phase 1 clinical trials. Compounds derived from Shattuck’s proprietary Agonist Redirected Checkpoint, ARC®, platform simultaneously inhibit checkpoint molecules and activate costimulatory molecules within a single therapeutic. The company’s SL-172154 (SIRPa-Fc-CD40L) program, which is designed to block the CD47/SIRPa checkpoint interaction and simultaneously agonize the CD40 pathway, is being evaluated in two Phase 1 trials. A second product candidate, SL-279252 (PD1-Fc-OX40L), is being evaluated in a Phase 1 trial in solid tumors or lymphomas. Additionally, the company is advancing a proprietary Gamma Delta T Cell Engager, GADLEN™, platform, which is designed to bridge gamma delta T cells to tumor antigens for the treatment of patients with cancer. Shattuck has offices in both Austin, Texas and Durham, North Carolina. For more information, please visit:

About the Position
Shattuck Labs is seeking a highly motivated individual that will join a dynamic R&D team in Research Triangle Park, NC to support the planning, development and execution of in vitro and in vivo pre-clinical assays for validating a novel class of therapeutics that target T-cells. The candidate must be comfortable working both independently on novel discovery-based projects and also under the supervision of the R&D team. It is expected that the individual has a strong foundation in T-cell biology and cancer research, to not only perform experiments, but also contribute knowledge and ideas to future discovery programs at Shattuck Labs. This position will report to the Vice President of R&D/GADLEN and is a full-time position based in Research Triangle Park, NC. Shattuck will provide a competitive compensation and benefits package.

Summary of Key Responsibilities:
• Design and execute human and mouse T-cell based functional assays to understand the mechanism of action of novel therapeutic candidates.
• Design, develop and validate in vivo mouse tumor model studies to confirm the mechanism of action of therapeutic candidates.
• Performing immunophenotyping and gene profiling experiments using a variety of techniques including but not limited to multiparameter flow cytometry and mRNA profiling, e.g. single-cell RNAseq.
• Genetically manipulate mammalian cell lines and primary immune cells with standard molecular biology techniques including Lentiviral transduction systems and genome editing technology such as CRISPR
• Molecular characterization of candidates using ELISA, Western blot, qPCR, luciferase reporter assays, live-cell imaging, and flow cytometry/FACS based techniques
• Interact with multiple colleagues in a dynamic environment and mentor junior staff
• Be willing to take on new projects outside the ‘normal’ course of business
• Data interpretation, manuscript preparation, publication and presentation of results
• Proficiently communicate research plans and findings at team, department meetings and conferences

Job Requirements

Required Qualifications and Skills
• Ph.D. in Immunology/Cancer Biology with a focus on T-cell biology.
• 1-3 years of hands-on academic or industry research experience (postdoc or scientist level positions) is highly desired.
• Experience in studying gamma delta T cell biology is preferred.
• Experience in mouse tumor mouse model systems. Hands on experience with humanized mouse models is a plus.
• Experience in multiplex flow cytometry.
• Must have the ability to multi-task to meet critical deadlines and the independent initiative to solve interdisciplinary problems.
• Candidate must be able to thrive in a fast-paced dynamic biotech environment where flexibility, tolerability to rapid change, and drive to make a significant impact is essential.
• Must enjoy working in collaboration with other team members within and outside the department to achieve goals through effective building of relationships.
• Computer proficiency; MS word, excel, powerpoint, Graphpad prism, flowjo, etc
(Job number: 4050179)
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