Job: Scientist, Shattuck Labs, Durham, NC
About Shattuck Labs
Shattuck Labs (www.shattucklabs.com) is developing breakthrough therapies for immunotherapy, which harnesses the human immune system to improve survival for patients battling cancer and inflammatory disease. Shattuck has pioneered the development of dual-sided Fc fusion proteins with the Agonist Redirected Checkpoint (ARC) and Gamma Delta T-Cell Engager (GADLEN) platform technologies. Two compounds from the ARC platform are currently being tested in clinical trials (SL-279252 and SL-172154). In multiple published studies, ARC therapeutics have significantly outperformed traditional antibody-based therapeutics, and we believe that the dual-functionality of the ARC platform positions our product candidates with best-in-class potential as compared to traditional antibody therapeutics. Over 300 product candidates have been generated from the ARC platform and are poised for IND-enabling studies. Shattuck Labs, based in Austin, Texas, is a privately held biotechnology company founded in 2016. The R&D hub for Shattuck Labs is based in Research Triangle Park, NC.
About the Position
Shattuck Labs is seeking a highly motivated individual that will join a dynamic R&D team in Research Triangle Park, NC to support the planning, development and execution of in vitro and in vivo pre-clinical assays for validating a novel class of therapeutics that target T-cells. The candidate must be comfortable working both independently on novel discovery-based projects and also under the supervision of the R&D team. It is expected that the individual has a strong foundation in T-cell biology and cancer research, to not only perform experiments, but also contribute knowledge and ideas to future discovery programs at Shattuck Labs. This position will report to the Vice President of R&D/GADLEN and is a full-time position based in Research Triangle Park, NC. Shattuck will provide a competitive compensation and benefits package.
Summary of Key Responsibilities:
• Design and execute human and mouse T-cell based functional assays to understand the mechanism of action of novel therapeutic candidates.
• Design, develop and validate in vivo mouse tumor model studies to confirm the mechanism of action of therapeutic candidates.
• Performing immunophenotyping and gene profiling experiments using a variety of techniques including but not limited to multiparameter flow cytometry and mRNA profiling, e.g. single-cell RNAseq.
• Genetically manipulate mammalian cell lines and primary immune cells with standard molecular biology techniques including Lentiviral transduction systems and genome editing technology such as CRISPR
• Molecular characterization of candidates using ELISA, Western blot, qPCR, luciferase reporter assays, live-cell imaging, and flow cytometry/FACS based techniques
• Interact with multiple colleagues in a dynamic environment and mentor junior staff
• Be willing to take on new projects outside the ‘normal’ course of business
• Data interpretation, manuscript preparation, publication and presentation of results
• Proficiently communicate research plans and findings at team, department meetings and conferences
Required Qualifications and Skills
• Ph.D. in Immunology/Cancer Biology with a focus on T-cell biology.
• 1-3 years of hands-on academic or industry research experience (postdoc or scientist level positions) is highly desired.
• Experience in studying gamma delta T cell biology is preferred.
• Experience in mouse tumor mouse model systems. Hands on experience with humanized mouse models is a plus.
• Experience in multiplex flow cytometry.
• Must have the ability to multi-task to meet critical deadlines and the independent initiative to solve interdisciplinary problems.
• Candidate must be able to thrive in a fast-paced dynamic biotech environment where flexibility, tolerability to rapid change, and drive to make a significant impact is essential.
• Must enjoy working in collaboration with other team members within and outside the department to achieve goals through effective building of relationships.
• Computer proficiency; MS word, excel, powerpoint, Graphpad prism, flowjo, etc