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Job: Research Associate IV, Shattuck Labs, Durham, NC

General Information

Job title:
Research Associate IV
Job location:
Durham, NC  27709 United States
Requisition code:
Date posted:
Job category:
Research and Development
Employment type:
Full time

Job Description

About Shattuck Labs
Shattuck Labs ( is developing breakthrough therapies for immunotherapy, which harnesses the human immune system to improve survival for patients battling cancer and inflammatory disease. Shattuck has pioneered the development of dual-sided Fc fusion proteins with the Agonist Redirected Checkpoint (ARC) and Gamma Delta T-Cell Engager (GADLEN) platform technologies. Two compounds from the ARC platform are currently being tested in clinical trials (SL-279252 and SL-172154). In multiple published studies, ARC therapeutics have significantly outperformed traditional antibody-based therapeutics, and we believe that the dual-functionality of the ARC platform positions our product candidates with best-in-class potential as compared to traditional antibody therapeutics. Over 300 product candidates have been generated from the ARC platform and are poised for IND-enabling studies. Shattuck Labs, based in Austin, Texas, is a privately held biotechnology company founded in 2016. The R&D hub for Shattuck Labs is based in Research Triangle Park, NC.

About the Position
Shattuck Labs is seeking a highly motivated individual that will join a dynamic R&D team in Research Triangle Park, NC to support the planning, development and execution of in vitro and in vivo pre-clinical assays for validating a novel class of therapeutics that target T-cells. The candidate must be comfortable working both independently on novel discovery-based projects and also under the supervision of the R&D team. It is expected that the individual has a strong foundation in T-cell biology and cancer research, to not only perform experiments, but also contribute knowledge and ideas to future discovery programs at Shattuck Labs. This is a full-time position based in Research Triangle Park, NC. Shattuck will provide a competitive compensation and benefits package.

Summary of Key Responsibilities
• Work closely with principal scientists on the team to perform semi-high throughput in vitro and cell-based potency assays to screen multiple fusion protein candidates.
• Use various transfection modalities including Lentivirus/Retrovirus systems to generate stable mammalian cell lines for the generation of reporter assays.
• Molecular characterization of fusion protein candidates using chemiluminescent and MSD-based ELISA, Western blot, qPCR, luciferase reporter assays, live-cell imaging, and flow cytometry/FACS based techniques.
• Collect and analyze data and maintain compliant records of laboratory research.
• Co-author technical documentation (abstracts, manuscripts and project reports) from basic pre-clinical development.
• Proficiently communicate research plans and findings at team, department meetings and conferences.

Job Requirements

Required Qualifications and Skills
• The successful candidate will hold a degree in one of the following fields, or similar; Biology, Biochemistry, Molecular Biology or Immunology
o B.S. degree, and candidates with M.S. encouraged to apply
• 2-3 years of experience in an academic lab, biotech or pharma laboratory conducting hypothesis-driven research.
• Experience in multiplex flow cytometry.
• Experience in aseptic cell culture techniques and ability to generate stable mammalian cell lines.
• Proven ability to collaborate with other functional areas within the company.
• Able to multi-task productively, applying time management processes and procedures effectively for on time delivery.
• Candidate must be sharp, self-motivated, and able to thrive in a fast-paced dynamic biotech environment where flexibility, tolerability to rapid change, and drive to make a significant impact is essential.
• Excellent oral and written communication skills.
• Must enjoy working in collaboration with others and small teams to achieve goals through effective building of relationships with co-workers
(Job number: 4013523)
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