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Job: Senior Research Scientist, Therapeutic Discovery, StrideBio, Durham, NC

General Information

Job title:
Senior Research Scientist, Therapeutic Discovery
Job location:
Durham, NC  27709 United States
Requisition code:
Date posted:
DOE - Salary
Job category:
Research and Development
Employment type:
Full time

Job Description

StrideBio is a product-driven, fully integrated gene therapy company focused on creating and developing innovative genetic medicines with life-changing or curative potential for patients with devastating conditions, including monogenic rare disease and beyond.

We leverage our proprietary structure-inspired adeno-associated virus (AAV) vector engineering platform (STRIVE) to create unique and differentiated vectors that improve upon naturally occurring AAV serotypes to overcome current limitations of first-generation gene therapies. Combined with our genetic construct design expertise and in-house manufacturing capabilities, StrideBio is positioned to generate best-in-class genetic medicines that allow more patients to benefit with maximum efficiency, leading to improved treatment outcomes.

Our team is comprised of accomplished leaders and talented, passionate colleagues with a desire to translate innovative science into treatments. Together with our collaborators we are making rapid progress on our mission to bring novel medicines to patients who desperately need them. StrideBio's offices, labs and manufacturing facility are located in the heart of Research Triangle Park, NC, within 10 miles of downtown Durham and Raleigh-Durham International Airport. Please visit to learn more.


We seek a motivated Senior Research Scientist to join the Therapeutic Discovery group responsible for discovering lead recombinant adeno-associated virus (rAAV) vectors for preclinical development. You will lead one or more projects and/or programs to enable the discovery and evaluation of novel rAAV therapies. You will be expected to drive scientific strategy and independently design and execute experiments using a wide variety of cell and molecular biology techniques in order to test the therapeutic potential of rAAV vectors. This position requires a strong cell biology and neuroscience background. This is an approximately 50% lab-based position in a BSL II material laboratory.


Contribute to and drive scientific strategy for Therapeutic Discovery programs
Act as the scientific lead on a specific disease program or platform project
Independently design and execute experiments using cell-based assays
Independently analyze and interpret data and present results to project teams
Conduct complex molecular cloning and preparation of rAAV transgene constructs
Perform advanced plasmid DNA purification by miniprep and maxiprep
Maintain multiple cell types in culture (primary rodent cells, differentiated iPSCs), perform transient transfection and rAAV transduction experiments for gene expression
Develop and optimize mRNA (qPCR), protein (ELISA, Western blot, ICC) and functional assays (calcium imaging, multi-electrode arrays)
May manage external projects and/or programs
Manage one of more staff of scientists and/or research associates
Manage interactions with external parties such as vendors, CROs, etc.
Contribute to technology development related to cell biology
Ensure accurate and up-to-date records of laboratory activities via electronic documentation
Technical writing of procedures, protocols, and reports
Monitor, maintain and update knowledge of instrumentation and laboratory needs
Execute laboratory work plan/schedule developed with input from supervisor or senior team members

Job Requirements


Ph.D. in neuroscience, molecular biology, cell biology or other relevant scientific area with 5+ years experience
Cell culture experience is required
Cell-based assay development experience is required
Experience with rAAV expression vector design
Strong written and verbal communications, including critical thinking skills
Demonstrated experience effectively managing multiple projects and staff and troubleshooting experiments, and is an excellent problem-solver who thrives on solving scientific challenges
Must be a self-motivated and driven professional who can effectively perform in a rapidly changing, small company environment
Must be able to work independently, but is also a team player with strong collaborative skills
Must have strong attention to detail, along with strong organizational and documentation (inclusive of notebook management) skills


Previous drug discovery and project management experience is desired
Relevant knowledge and industrial experience in the field of gene therapy development is preferred
Strong background in CNS and cardiac biology


We offer a competitive salary and excellent benefits package including:

Stock Options and Bonus
Medical, Dental, and Vision health insurance
Matching 401k plans (both Pre-tax and Roth Post-tax)
Life/AD&D, Long-term and Short-term disability
Employee Assistance Program
Voluntary: Supplemental Life, Critical Illness, Group Accident, Hospital Indemnity, Identity Theft Protection

Additionally, we provide the following perks:

Relocation Services
Retail Member Discount Programs
Complimentary onsite gym membership
Fully stocked kitchen
Socials, happy hours, and other events throughout the year (currently "virtual")

For more information, or to apply now, you must go to the website below. Please DO NOT email your resume to us as we only accept applications through our website.
(Job number: 3982446)
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