Job: Scientific Associate II (TD Purification), Seqirus, Holly Springs, NC
Come join a company that tackles fascinating problems and find solutions to complex challenges. With deep expertise in influenza science, our team works on cutting-edge research, pioneering technologies to optimise the manufacturing process and improve the effectiveness of influenza vaccines. We operate as one integrated global organisation, drawing together expert staff from different countries to collaborate. Together, we are working on the front line to protect communities from seasonal influenza and global pandemic threats. When you join Seqirus, you join a team dedicated to making a difference in people's lives. It's a feeling of possibility, creativity, and purpose that inspires us every day.
The person in this role will support TD downstream projects including developing, defining, and implementing purification processes, driving continuous improvements, and providing commercial support for influenza vaccines.
Partner with diverse team members from various functions, countries and members at various levels in the organization.
Solve complex problems using analytical thinking gained through formal education and/or previous roles.
Both independently and collaboratively design and execute small scale experiments to characterize and define bioprocess steps.
Independently operate small scale bioprocess equipment including TFF, NFF, centrifugation, and column chromatography systems.
Provides on-going support on projects of varying size often under tight deadlines, including guidance to others as needed, applying knowledge of broader project objectives to provide input that furthers project success.
Perform in-process analytics to characterize/quantify vaccine antigens and impurities.
Understand and interpret experimental data and results to support decisions and definition / knowledge of purification processes.
Understand and apply bioprocess scale-up strategies.
Prepare technology development study protocols and reports in support of process transfer and regulatory documents
Communicate (presentations, write-up in technical documents, etc.) results to colleagues, project teams, management and external partners.
Be accountable for developing own self to enhance contribution.
Function effectively as a core team member.
Bachelor’s Degree in related scientific or engineering field with 3+ years related experience or Master’s Degree in related scientific field with 0+ years related experience
Knowledge of bioprocess unit operations (e.g. chromatography, centrifugation, precipitation, TFF and NFF filtration) and engineering scaling principles
Understanding/experience with protein biochemistry and/or nucleic acids
Experience with GE AKTA chromatography systems/Unicorn software and lab/pilot scale TFF systems is desired
Demonstrated knowledge of / expertise with analytical methods (e.g. SDS PAGE, Western Blot, HPLC, ELISA, Picogreen) is a plus
Knowledge of and experience in application of statistical techniques such as Design of Experiments (DOE) is desired
Knowledge of GLP/GMP preferred
Ability to work with cross functional teams
Strong communication skills, technical writing ability, and good attention to detail
Must be a self-starter and able to work with minimal supervision