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Job: Engineer - Devices and Consumables, Xilis, Inc, Durham, NC

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General Information

Job title:
Engineer - Devices and Consumables
Job location:
Durham, NC  27701 United States
Requisition code:
Date posted:
Job category:
Employment type:
Full time

Job Description

Xilis, Inc is a Duke startup founded by Duke professors David Hsu (M.D./Ph.D) and Xiling Shen (Ph.D) in Durham, North Carolina. The company has been developing cutting-edge Patient-Derived MicroOrganospheres (PDMOs) technology for precision cancer diagnostics and drug development. Xilis’ transformative platform recreates patient-specific tumors in their 3D and environmental complexity at micro-scale ex-vivo, allowing ultra-high-throughput, clinically-relevant, and affordable experimental selection of the safest, most effective drugs for each and every patient in a matter of days. The company is funded by Silicon Valley and New York venture firms that are leaders in the healthcare space and have invested in top precision medicine companies including Foundation Medicine and Guardant Health.


The successful candidate will join Xilis’ critical hardware engineering functions, spanning consumables and device research, development, and manufacturing. As an early member of the technology development team, the successful candidate will play a pivotal role in pushing the boundaries of microfluidics and device development to further the usability of Xilis’ proprietary PDMOs for a wide variety of applications. The successful candidate will be primarily responsible for contributing to the advancement of microfluidic devices and the associated systems to process clinical samples consistently, inexpensively, and at the highest levels of quality. The candidate will serve as a key player in company-wide activities affecting R&D and product development, in particular to guarantee the best possible user experience for internal and external stakeholders - as such, he or she will interface frequently with the Software Engineering, Biomedical R&D, Operations, and Business Development functional groups. The candidate will report to the Senior Engineer of Devices and Consumables.

By joining the team at an early stage, the candidate will have an outsized impact on fundamentally advancing precision cancer care. In the next few months and years, the candidate will:

Participate in the design and development of a new generation of microfluidic devices optimized to facilitate the adoption of PDMOs as a new standard in diagnostic and therapeutic applications
Gather feedback from device users and work closely with the Senior Engineer of Devices and Consumables to continuously improve the performance of current systems
Contribute to the development and manufacturing of the company’s commercial-grade devices
CAD, order, build, assemble, test, and iterate on mechanical, software, and microfluidic components under the guidance of the Senior Engineer of Devices and Consumables
Run experiments at the interface of engineering and biology
Move quickly to advance the technology, and positively engage with the rest of the engineering team to maintain a culture of fast-paced engineering progress
Help with troubleshooting of manufacturing and laboratory issues as quickly as possible
Perform support tasks across the company as needs arise
Participate in company wide activities as an early member of the R&D team

Job Requirements


The ideal candidate should have:

A degree in science or engineering and 3+ years of experience in developing biotechnology consumables and/or devices in an academic or industrial context
Having developed technology for biopharma applications is a plus
A bias for action and a demonstrated work ethic required to succeed in an early stage startup
Demonstrated troubleshooting and problem solving experience
Working knowledge of microfluidics is a plus
Familiarity with SolidWorks and other CAD design software is a plus
Experience in regulated environments is a plus
Experience in early stage start-ups a plus
(Job number: 3925271)
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