Job: Associate Director, Preclinical Development, StrideBio, Durham, NC
Associate Director, Preclinical Development
Durham, NC 27709 United States
medical, dental, vision, 401k with employer match, paid time off, company paid holidays
StrideBio is a product-driven, fully integrated gene therapy company focused on creating and developing innovative genetic medicines with life-changing or curative potential for patients with devastating conditions, including monogenic rare disease and beyond.
StrideBio leverages its proprietary structure-inspired adeno-associated virus (AAV) vector engineering platform (STRIVE) to create unique and differentiated vectors that improve upon naturally occurring AAV serotypes to overcome current limitations of first-generation gene therapies. Combined with our gene construct expertise and in-house manufacturing capabilities, StrideBio is positioned to generate best-in-class genetic medicines that allow more patients to benefit with maximum efficiency.
StrideBio is leveraging its STRIVE platform to develop AAV vectors that improve upon naturally occurring AAV serotypes, overcoming current limitations of first-generation gene therapies. StrideBio's vectors have been engineered to present a unique sequence of modified surface domains that avoid recognition by pre-existing neutralizing antibodies, creating potential to expand the treatment-eligible population. These same surface residues which are involved in neutralizing antibody interactions also influence other functional aspects of the vectors. As a result, StrideBio's unique and differentiated vectors also allow for:
Improved tissue targeting and de-targeting
Increased potency and transduction efficiency
Improved manufacturability at scale
StrideBio's product-driven approach includes fully integrated discovery, development and manufacturing capabilities. In addition to developing novel vectors, our gene construct expertise enables the development of multiple genetic medicine modalities to advance lead product candidates, with the in-house manufacturing capability to scale and support clinical development.
We seek a driven and accomplished Associate Director to lead our Preclinical Development team. You will be responsible for developing preclinical strategies, overseeing projects and managers across discovery pipelines, and working closely with cross-functional teams.
Primarily, you will oversee multiple AAV-based gene therapy discovery pipelines in CNS rare genetic diseases.
Strategize and oversee preclinical development plans across multiple gene therapy discovery pipelines
Monitor research progress and milestones across programs
Provide operational and technical leadership to project managers
Design and monitor preclinical in vivo studies, as well as oversee research and development at the bench
Work closely with manufacturing to ensure alignment across teams
Collaborate with and manage cross-functional teams
Oversee GLP tox studies
Manage and mentor junior staff
Select and communicate with CROs and external collaborators
Write and review reports, contributing to regulatory submissions, regularly presenting and discussing data
KNOWLEDGE AND SKILLS:
PhD in a relevant discipline such as biology, pharmacology, genetics, or neuroscience
5+ years industry experience
5+ years relevant management experience
5+ years' experience in CNS biologic therapies and/or CNS rare genetic disease therapeutics is desired
Proven track record in CNS and/or rare genetic disease biologic therapeutics
Ability to be decisive in situations where limited information is available, and quick decisions are required
Experience managing a team of scientists as well as collaborating with cross-functional teams
Experience designing and implementing in vivo studies
Strong oral and written communication skills
Experience in IND submissions preferred
Experience with AAV vectors preferred
Must be a self-motivated and driven professional who can effectively perform and achieve deadlines in a rapidly changing, small company environment
Must be able to work independently but is also a team player with strong collaborative skills
COMPENSATION & BENEFITS
We offer a competitive salary and excellent benefits including stock options, PTO, Medical, Dental, Vision, 401k match, disability and life insurance. Additionally, we provide the following perks:
Complimentary onsite gym membership
Fully stocked kitchen
Socials, happy hours and other events throughout the year
Access to an onsite full-service restaurant (Mid-2020)
Access to an onsite massage therapist (Mid-2020)
For more information, or to apply now, you must go to the website below. Please DO NOT email your resume to us as we only accept applications through our website.
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