Job: Senior Scientist, Process Development, StrideBio, Research Triangle Park, NC
Senior Scientist, Process Development
Research Triangle Park, NC 27709 United States
medical, dental, vision, 401k with employer match, paid time off, company paid holidays
Manufacturing and Production
StrideBio is a product-driven, fully integrated gene therapy company focused on creating and developing innovative genetic medicines with life-changing or curative potential for patients with devastating conditions, including monogenic rare disease and beyond.
StrideBio leverages its proprietary structure-inspired adeno-associated virus (AAV) vector engineering platform (STRIVE) to create unique and differentiated vectors that improve upon naturally occurring AAV serotypes to overcome current limitations of first-generation gene therapies. Combined with our gene construct expertise and in-house manufacturing capabilities, StrideBio is positioned to generate best-in-class genetic medicines that allow more patients to benefit with maximum efficiency.
StrideBio is leveraging its STRIVE platform to develop AAV vectors that improve upon naturally occurring AAV serotypes, overcoming current limitations of first-generation gene therapies. StrideBio's vectors have been engineered to present a unique sequence of modified surface domains that avoid recognition by pre-existing neutralizing antibodies, creating potential to expand the treatment-eligible population. These same surface residues which are involved in neutralizing antibody interactions also influence other functional aspects of the vectors. As a result, StrideBio's unique and differentiated vectors also allow for:
Improved tissue targeting and de-targeting
Increased potency and transduction efficiency
Improved manufacturability at scale
StrideBio's product-driven approach includes fully integrated discovery, development and manufacturing capabilities. In addition to developing novel vectors, our gene construct expertise enables the development of multiple genetic medicine modalities to advance lead product candidates, with the in-house manufacturing capability to scale and support clinical development.
The purpose of this position is to lead efforts to define and characterize a robust manufacturing process to support early phase clinical production of AAV viral vectors.
We seek a talented Senior Scientist to join our Process Development group. The successful candidate will lead upstream and downstream process development and characterization for manufacturing of recombinant adeno-associated viral (AAV) vectors. You will be proficient in mammalian cell culture, chromatography, and bring a proven track record of successful process development. In addition, you will manage the work of junior scientists. This is a >50% lab-based position.
Independently design, execute, and analyze experiments optimizing production and purification of AAV.
Directly supervise the daily activities of the Process Development Lab manage experiments, equipment, inventory, and workloads.
Support large-scale manufacturing runs and ensure timely delivery of materials to internal and external partners.
Author method development and characterization reports and SOPs.
Perform other responsibilities as needed.
KNOWLEDGE AND SKILLS:
Master's Degree or higher in Chemistry, Chemical Engineering, Biochemistry, Biotechnology, or related and 8+ years' experience, or PhD degree preferred, with 2+ years' experience.
Practical experience with FPLC is a must, ideally at both Lab and Pilot scales.
Experience with suspension cell culture at all scales: flasks, bench-top bioreactors, and large-scale single-use bioreactors is preferred.
Experience with other aspects of downstream purification (e.g. clarification/filtration, TFF, density ultracentrifugation, etc.) is required.
Specific experience with recombinant viral vector purification is preferred.
Proficiency with MS Excel, GraphPad Prism, and electronic lab notebooks is essential.
Proficiency designing, executing, and analyzing DOE is highly desired.
Must have excellent verbal and written communication skills.
Must have demonstrated experience effectively managing multiple projects and staff and troubleshooting experiments, and is an excellent problem-solver who thrives on solving scientific challenges.
Must be a self-motivated and driven professional who can effectively perform in a rapidly changing, small company environment.
Must be able to work independently, but is also a team player with strong collaborative skills.
COMPENSATION & BENEFITS
We offer a competitive salary and excellent benefits including stock options, PTO, Medical, Dental, Vision, 401k match, disability and life insurance. Additionally, we provide the following perks:
Complimentary onsite gym membership
Fully stocked kitchen
Socials, happy hours and other events throughout the year
Access to an onsite full-service restaurant (Mid-2020)
Access to an onsite massage therapist (Mid-2020)
For more information, or to apply now, you must go to the website below. Please DO NOT email your resume to us as we only accept applications through our website.
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