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Job: Research Associate, Upstream Process Development, StrideBio, Research Triangle Park, NC

General Information


Job title:
Research Associate, Upstream Process Development
Job location:
Research Triangle Park, NC  27709 United States
Requisition code:
429368
Date posted:
03/13/2020
Compensation:
medical, dental, vision, 401k with employer match, paid time off, company paid holidays
Job category:
Manufacturing and Production
Employment type:
Full time

Job Description


StrideBio is a product-driven, fully integrated gene therapy company focused on creating and developing innovative genetic medicines with life-changing or curative potential for patients with devastating conditions, including monogenic rare disease and beyond.

StrideBio leverages its proprietary structure-inspired adeno-associated virus (AAV) vector engineering platform (STRIVE) to create unique and differentiated vectors that improve upon naturally occurring AAV serotypes to overcome current limitations of first-generation gene therapies. Combined with our gene construct expertise and in-house manufacturing capabilities, StrideBio is positioned to generate best-in-class genetic medicines that allow more patients to benefit with maximum efficiency.

StrideBio is leveraging its STRIVE platform to develop AAV vectors that improve upon naturally occurring AAV serotypes, overcoming current limitations of first-generation gene therapies. StrideBio's vectors have been engineered to present a unique sequence of modified surface domains that avoid recognition by pre-existing neutralizing antibodies, creating potential to expand the treatment-eligible population. These same surface residues which are involved in neutralizing antibody interactions also influence other functional aspects of the vectors. As a result, StrideBio's unique and differentiated vectors also allow for:

Improved tissue targeting and de-targeting
Increased potency and transduction efficiency
Improved manufacturability at scale
StrideBio's product-driven approach includes fully integrated discovery, development and manufacturing capabilities. In addition to developing novel vectors, our gene construct expertise enables the development of multiple genetic medicine modalities to advance lead product candidates, with the in-house manufacturing capability to scale and support clinical development.



POSITION SUMMARY:

The purpose of this position is to perform experimentation to define and characterize the upstream process for manufacturing AAV viral vectors.

We seek a talented Research Associate to join the Process Development team. The successful candidate will independently execute and analyze experiments intended to improve and characterize StrideBio's proprietary AAV vector production platform. You will provide critical support to R&D and Manufacturing project areas. Additional responsibilities include general lab support and equipment monitoring and maintenance. Approximately 90% in the lab.

MAJOR RESPONSIBILITIES:

Perform cell culture operations including media and buffer preparation, maintenance of research and production. cell lines, generation and testing of cell banks.
Ensure prompt availability of cell culture stocks for experiments across project areas.
Maintain lab equipment and reagent inventories.
Meticulously record data in an organized and timely manner.

Job Requirements


Preferred Skills

Experience performing transfections.
Experience producing recombinant viral vectors.
Brightfield and epifluorescence microscopy of live or fixed cells.
Prior hands-on experience with rocking or stirred-tank bioreactors.
Data entry in an electronic lab notebook.
KNOWLEDGE AND SKILLS:

B.S./B.A. in Cell Biology, Biotechnology, Bioengineering, or related discipline.
Experience maintaining and expanding mammalian cells thawing, passaging, banking.
Ability to work productively in a team environment and independently and efficiently perform assigned tasks.
Effective problem-solving skills.
Proficiency with MS Office, particularly Excel.
Detail-oriented with excellent organizational and communication skills.
Must be a self-motivated and driven professional who can effectively perform in a rapidly changing, small company environment.
Must be able to work independently, but is also a team player with strong collaborative skills.


COMPENSATION & BENEFITS

We offer a competitive salary and excellent benefits including stock options, PTO, Medical, Dental, Vision, 401k match, disability and life insurance. Additionally, we provide the following perks:

Complimentary onsite gym membership
Fully stocked kitchen
Socials, happy hours and other events throughout the year
Access to an onsite full-service restaurant (Mid-2020)
Access to an onsite massage therapist (Mid-2020)


For more information, or to apply now, you must go to the website below. Please DO NOT email your resume to us as we only accept applications through our website.

https://stridebio.applicantpool.com/jobs/429368-164763.html
(Job number: 3881872)
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