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Job: Associate Process Engineer/Process Engineer, Precision BioSciences, Durham, NC

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General Information


Job title:
Associate Process Engineer/Process Engineer
Job location:
Durham, NC  27701 United States
Requisition code:
Date posted:
02/07/2020
Compensation:
Job category:
Engineering
Employment type:
Full time

Job Description


Summary:

Precision BioSciences is currently seeking to fill the role of Associate Process Engineer or Process Engineer. This position will be a critical part of the team charged with developing a world-class manufacturing process for making an mRNA-based active pharmaceutical ingredient (API). The candidate will participate in all aspects of process development, including in-vitro transcription, downstream purification and testing of products and intermediates.

Responsibilities:

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

Set up and run transcription reactions at small and large scale
Assist in the development of downstream purification operations appropriate to the scale of the process
Collaborate with the Analytical team to perform in-process and final product testing
Perform incoming raw material testing and prepare critical buffers and reagents
Operate and maintain a variety of production equipment, such as mixing vessels, peristaltic pumps, chromatography columns and lab instrumentation
Maintain accurate and complete lab records and other documentation
Participate in document (SOP, Batch Record, data reports) preparation and review; write and update process associated plans, protocols and reports for small and full-scale studies
Manage final product, process intermediate and raw material inventories
Participate in technology transfer to GMP production unit

Job Requirements


Education and Experience:

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Required:

MS in Chemical Engineering, Biological Engineering or relevant biological sciences discipline with 0-2 years of biopharma industry experience or equivalent (or) BS in Chemical Engineering, Biological Engineering or relevant biological sciences discipline with 2+ years of biopharma industry experience or equivalent
Familiarity with standard purification techniques (membrane filtration, depth filtration, tangential flow filtration)
Knowledge of chromatography principles (IEX, SEC, HIC, Affinity)
Strong wet chemistry lab skills, including preparing buffers, handling glassware, working with chemicals and solvents and operating safely in a dynamic R&D environment
Preferred:

Familiarity with AKTA, Agilent Chromatography systems
Understanding of GMP regulations for biologics manufacturing
Ability to define problems, collect and analyze data, establish facts and draw valid conclusions
Good working knowledge of nucleic acid chemistry, including appropriate handling procedures
Comfortable working with sophisticated manufacturing and analytical equipment, including managing calibration programs
Experience with standard molecular biology skills, including running Agarose, denaturing PAGE gels, ELISA, UV/Vis testing, qPCR and protein testing
Experience using GE UNICORN and Agilent CHEMSTATION
Strong communication skills in English, both written and verbal
Software skills including Excel, Word, and statistical software
Ability to define problems, collect and analyze data, establish facts and draw valid conclusions
The ability to work both independently and in a collaborative environment
Travel Requirements

This position may require limited travel (up to 5%)
Precision BioSciences’ mission is to translate the world’s most powerful genome editing technology into greatly needed products throughout the life sciences. Precision’s wholly proprietary ARCUS genome editing platform enables the production of highly specific nucleases that can insert, remove, and modify DNA at essentially any location in a complex genome. Precision BioSciences’ vision is to be the conduit through which the greatest genome engineering challenges are solved. Precision is developing genome editing-based products to address critical needs in oncology, genetic disease, agriculture, and beyond. For additional information, please visit www.precisionbiosciences.com.

Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
(Job number: 3875759)
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