Job: Research Scientist I – Autoimmunity/Inflammation/In Vivo Pharmacology, Heat Biologics, Inc., Durham, NC
Heat Biologics is a public biotechnology company focused on the development and commercialization of novel immunomodulators and cancer immunotherapy products. We are an innovative and growing company and have a highly energized and accomplished team.
We are seeking a highly motivated immunology PhD scientist with expertise in autoimmunity and inflammation as it relates to animal models and immunoassay, development, for the role of Research Scientist I. The position will be based in Research Triangle Park, North Carolina and will directly report to the Executive Director of Research in the Heat Research Group (HRG). This role will be responsible for building out a new function focused on testing drug candidates for efficacy in animal models of inflammation and will represent a subject matter expert for inflammation & autoimmune indications in the lab.
This is a wet lab function; you will perform studies and be responsible for mentoring and training technicians. This function has no direct reports, it is an individual contributor role and will complement similar cancer immunology roles internally. This role will be required to build study designs that is in-line with the company’s goals, analyze results, build study reports and present results internally.
You will work in a team and support preclinical development of novel immunology, small and large molecule, preclinical programs. Your responsibilities will include the development and execution of experimental strategies to define biomarkers of target engagement, mechanism of action and mechanism of resistance to therapeutic agents. You will perform in vitro and in vivo experiments to determine the functional effect of candidate target activation/inhibition by using a variety of assays to interrogate immune endpoints. You will be expected to keep abreast of published scientific literature and present your data at internal group meetings. You will also be responsible for synthesizing study reports, scientific posters and manuscripts.
The successful candidate will be an individual contributor with deep scientific curiosity, excellent oral and written communication skills, work well independently and as part of a collaborative team.
• Expertise and deep knowledge in immunology, autoimmunity, tolerance and inflammation is required
• Hands-on experience with the development of in vivo mouse models for inflammation and autoimmune diseases required
• Expertise with multi-parameter flow cytometry and analysis software, developing in vitro and in vivo assays to investigate immune function and possessing a deep knowledge of technologies commonly used to assess immune endpoints, required
• Hands-on, working experience with various immunoassay techniques such as T & B-cell ELISPOTs, cytokine ELISAs, measuring serum Ab titers, and Western blots, required
• Candidate should be competent in standard scientific software used for data analysis (e.g., Microsoft Excel) as well as Microsoft Word, PowerPoint, FlowJo and GraphPad Prism
• Ability to adapt to rapid changes in project priorities, define and meet aggressive timelines
• Committed to working in a small, collaborative manner across functional areas within a matrixed organization
• Candidate will be required to keep a notebook and record findings. Good data handling and recording skills as well as the ability to interpret moderately complex data sets and draw appropriate conclusions, required
• Candidate should be a strong team player with demonstrated ability to work independently to design experiments, interpret data, troubleshoot and suggest next steps
• PhD in immunology
• Completed postdoctoral fellowship (3 years minimum) in a relevant discipline – inflammation or autoimmunity
• 0-2 years of industry experience
• 5+ years of working, hands-on experience with in vivo mouse model development for inflammatory diseases
• 5+ years of working, hands-on experience in vitro/ex vivo immunoassay development
• 5+ years of flow cytometry and data analysis experience
• 4+ years technical experience with mammalian cell culture and molecular biology techniques as it relates to this job description
Knowledge in these areas a plus, but not required, for this position:
• Pharmacodynamic models such as DTH, Air-pouch model (APM), Acute DSS-induced and TNBS-induced IBD, CAIA arthritis, and acute dermatitis
• Human immunology experience and working with human PBMCs
• Knowledge with GVHD models and assays
• Knowledge of therapeutic areas including Rheumatology, GI, Neuroimmunology, and/or Respiratory
• Experience mentoring and training technicians