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Job: Analytical Technician, Lindy Biosciences, Durham, NC

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General Information

Job title:
Analytical Technician
Job location:
Durham, NC  27709 United States
Requisition code:
Date posted:
Commensurate with Experience
Job category:
Research and Development
Employment type:
Full time

Job Description

Company Description:
Lindy Biosciences is a development-stage company addressing formulation challenges in the rapidly growing biologics market. Our proprietary technology, Microglassification, produces spherical, dense, stable particles of a biologic, ideal for high-concentration suspensions enabling subcutaneous injection. This improves patient compliance, decreases costs, and enables new high-dose molecules to reach the market.

Microglassification is a process that gently dehydrates solutions of proteins, or other biologics, resulting in solid, spherical, amorphous microparticles. In this dry state, biologics are often stable enough for long-term storage, transport, or incorporation into drug delivery formulations.

Biological molecules such as monoclonal antibodies often require dosing of several hundred mg. In order to allow subcutaneous administration, which can only accommodate 1-2 mL of volume, the protein must be formulated at high concentration (>200 mg/mL). However, the viscosity of solutions of these molecules increases dramatically above 100 mg/mL, making injection prohibitively difficult.

Suspensions of protein particles produced with the Microglassification process can have a much lower viscosity than solutions of the same concentration. Preliminary formulations using our technology have been injectable through a 27G needle at >500 mg/mL.

Lindy Biosciences was founded in 2017. We have a dedicated team of unique thinkers and problem-solvers. As a start-up, every employee has a tremendous impact on our success, and we have abundant opportunity to learn, innovate, and challenge each other. We are passionate about improving our knowledge, skills, products, and ultimately improving the drug delivery experience for patients.

Position Description:
Lindy Biosciences is seeking an analytical technician to contribute to our R&D programs for cutting edge biologics delivery. This role will be responsible for the analysis and interpretation of internal and external samples and will play a crucial role in the development of our technology and the growth of our intellectual property portfolio.
This person will interact with all personnel at Lindy Biosciences and an eagerness and willingness to discuss, collaborate, innovate, and learn will be essential to the success of this role.
Primary activities will include chemical and physical properties analysis of therapeutic proteins, monoclonal and polyclonal antibodies, and complex mixtures of biologics in solutions, suspensions and various dispersions.
Testing may include a broad range of chromatographic and chemical techniques (GC, HPLC, KF), spectroscopic techniques (UV, IR, Raman), thermal techniques (DSC, TGA), physical techniques (PSA, SEM, Microscopy, Rheology, RI) and activity assays.
Hands-on experience is not required for all of these techniques, but awareness of these techniques will be helpful.

The Analytical Technician will be trained in the manufacture of small and large-scale batches of Microglassified™ particles and will assist in formulation development of said particles.

Job Requirements

Desired Applicant Experience:
- Degree in a relevant physical/biologic scientific field (e.g., Molecular Biology, Biochemistry, Pharmaceutical Sciences, etc.)
- 0-2 years experience
- Understanding of basic laboratory techniques, attention to detail, ability to manage multiple priorities, and strong communication skills
- Experience with method development, data review and analysis, protocol and report writing
- Experience with protein analytical methods (e.g., HPLC-SEC)

Preferred Applicant Experience:
- Experience with biologic drug substances
- Experience with dispersed dosage forms
(Job number: 3840929)
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