Research and Development
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Job: Molecular / Cellular Biology Postdoctoral Fellowship, UNC Catalyst for Rare Diseases, Chapel Hill, NC
Molecular / Cellular Biology Postdoctoral Fellowship
Chapel Hill, NC 27599 United States
Research and Development
A post-doctoral fellowship is available immediately for a highly motivated scientist interested in characterizing the impact of gene mutations at the molecular, biochemical and cellular levels. Research will be conducted in cell systems expressing postulated rare disease targets critical to the discovery of novel or repurposed drugs.
The UNC Catalyst for Rare Diseases (The Catalyst) in the School of Pharmacy at UNC is sponsored by the Eshelman Institute for Innovation and committed to understanding rare diseases caused by genetic mutations. The Catalyst is partnered with the Structural Genomics Consortium and Genetic Alliance in offering a critical resource to patient organizations needing laboratories to pursue rare disease biology.
Exploring the pathogenesis of rare diseases requires appropriate research tools. Gene editing technology allows the impact of genetic mutations to be evaluated through targeting gene editing. The Fellow will use molecular and cellular tools to explore the impact of mutations on biological pathways. A normal or mutated version of target protein will be used to create isogenic cell lines.
These tools will be made available within The Catalyst and to the external research community to allow rapid therapeutic lead identification and optimization. Collaborations exist to bring complementary screening tools, in vitro and in vivo models to bear on specific rare diseases.
The position offers professional and personal opportunities to work in an interdisciplinary collaborative team with links across the UNC campus and beyond and to engage with the rare disease patient and clinician community.
The project will involve a significant amount of molecular and cell biology lab work. Experience with gene manipulation using the latest editing technologies is highly desirable. In addition, experience with functional genomics, bioinformatics and next-generation sequencing is highly desirable.
The position requires a Ph.D. in a relevant field of study and a publication record demonstrating research productivity. Excellent communication, organization, writing and data analysis skills are also essential as well as a positive outlook and team- oriented attitude.
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North Carolina Biotechnology Center