Research and Development
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Job: Postdoctoral Associate, Duke Human Vaccine Institute, Durham, NC
Durham, NC 27710 United States
Research and Development
The Duke Human Vaccine Institute (DHVI), an international leader in the fight against major infectious diseases, is currently recruiting for Postdoctoral Associates to join our research team. The Duke Human Vaccine Institute is an interdisciplinary, interdepartmental institute dedicated to the study of basic and translational science required to understand host-pathogen interactions that can be translated to vaccines against human diseases. We are a team of highly interactive investigators that have expertise in immunology, molecular biology, virology, microbiology, computational biology, and vaccine science and are seeking a highly motivated recent PhD graduate who is interested in Molecular Biology or related scientific field to play an integral role in the following project under the direction of Dr. Wilton Williams.
A HIV-1 Envelope (Env) vaccine that elicits broadly neutralizing antibodies (bnAbs) has remained elusive, in part due to the limited understanding of the mechanisms of bnAb induction during natural infection. Recently developed simian-human chimeric immunodeficiency viruses (SHIVs) bearing Envs from HIV-1 transmitted-founder (TF) viruses associated with bnAb induction in HIV-1 infected adult individuals now provide an experimental model to establish the mechanisms of bnAb development. HIV-1 Env bnAbs develop in ~50% of chronically-infected adults in over 3-5 years of infection, but HIV-1-infected infants and children more frequently develop bnAbs and do so faster than adults. Understanding the cellular and molecular mechanisms of infant bnAb development will facilitate design of vaccine strategies to elicit bnAbs. This project will study neonatal immunity to novel SHIVs and help define neonatal bnAb immunity that can be recapitulated with a vaccine.
The DHVI has a dynamic mentoring program, and our postdoctoral associates work in concert with Duke faculty and staff in an invigorating research training environment. One of our primary scientific missions is to support and train early stage investigators to be the next generation of scientific leaders equipped to identify and implement solutions for improving human health worldwide.
DHVI functions as a vaccine development biotechnology enterprise, embedded within a top university. As a trainee within our mentoring program, you will interact with highly innovative and collaborative investigators and have the opportunity to master state of the art technologies. We are committed to providing an outstanding training environment and research experiences that will enhance your career and provide you an avenue to incorporate your education, expertise, initiative and dedication to the success of the studies. This is an opportunity to become part of a winning team that is working to discover novel ways to prevent infectious diseases.
The successful candidate will have a PhD or MD degree in a biological science or related field with molecular biology research experience. Must also be able to manage multiple and changing priorities in an interactive team environment with strong detail orientation and communication skills.
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North Carolina Biotechnology Center