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Job: Research Scientist, Biochemistry, Upstream Biotechnology, Durham, NC

General Information

Job title:
Research Scientist, Biochemistry
Job location:
Durham, NC  27701 United States
Requisition code:
Date posted:
Job category:
Research and Development
Employment type:
Full time

Job Description

About Upstream Biotechnology:

Founded in 2017 by scientists working at Duke University, Upstream Biotechnology is currently developing two platform technologies. First, we generate broad-spectrum disease resistance in crops using novel transcriptional and translational regulatory strategies. Second, we engineer plants to rapidly produce high quantities of recombinant proteins for research and therapeutic purposes.

Job Description:

The Research Scientist, Biochemistry is to work as part of the research and development team at our Durham, NC site. This is an exciting opportunity to participate in the development of a unique expression platform for the production of therapeutically relevant proteins.
Responsibilities will include the expression and purification of recombinant proteins and other tasks as assigned, while utilizing a broad repertoire of biochemistry techniques. These techniques include, but are not limited to: FPLC, gel electrophoresis, western blot, protein binding assays, and protein stability analysis. Proficiency in molecular cloning is also required of this position. The Research Scientist will prepare technical reports and presentations to illustrate and explain experiments, data, and conclusions.

Job Requirements

Position Requirements and Experience:

Strong verbal and written communication skills are essential to succeed in our fast-paced environment. The candidate must be able to work effectively in a team environment and collaborate with other scientists and associates. S/he is expected to maintain accurate, up-to-date records of experiments and promptly report results; good organizational skills are therefore essential. Additionally, the candidate must be motivated by hands-on laboratory work.


- Ph.D. in Biochemistry or a related scientific discipline. Applicants with a M.S. degree and exceptional qualifications will also be considered.
- Previous hands-on experience in protein biochemistry techniques including recombinant protein expression and purification, FPLC, in vitro activity assays, affinity binding assays, protein stability analysis, and post-translational modification analysis.
- Experience purifying recombinant antibodies or other protein biologics preferred.
- Experience in A. thaliana transformation by agrobacterium preferred.
- Working knowledge of cancer immunology preferred.
- Proficiency in molecular cloning is required.
- Proficiency with standard software and statistical analysis is required (e.g. Microsoft Office).
- Highly organized and detail-oriented.

To Apply:
Upstream Biotechnology provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Upstream Biotechnology complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

If you are interested in applying for this opportunity, please submit your resume or CV and cover letter to All submissions will be evaluated, and interviews will be conducted for those applicants who most closely fit our needs. If you are not contacted for an interview, your resume will remain on file and active for available positions for a period of one year.
(Job number: 3804147)
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