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Job: Functional Genomics/Tech Dev - Research/Senior Scientist, Element Genomics, Inc., Durham, NC

General Information

Job title:
Functional Genomics/Tech Dev - Research/Senior Scientist
Job location:
Durham, NC  27701 United States
Requisition code:
701 W Main Street
Date posted:
Job category:
Research and Development
Employment type:
Full time

Job Description

This is a mainly wet lab-based position within the functional genomics group at Element Genomics, a wholly owned subsidiary of UCB Biosciences. The role contributes at an in vitro technical level to design studies, produce and interpret data and contribute to current and future drug discovery projects. Skills should include molecular and cell biology knowledge together with previous experience of range of in vitro based technology capabilities and screening approaches.

Primary responsibilities :
• Design and execution of functional genomics assays/screens to identify and validate novel targets including assessment of relevant biology in screening models, and validation of hits
• Provide strategic guidance to maximize best applications of functional genomics technology and how it can be evolved to better address UCB needs in the future
• Development of novel in vitro assays for functional genomics screens
• Provide scientific insight and guidance in projects in consultation with UCB on functional genomics (medicinal chemists, cell biologists, disease area exerts, antibody engineers, etc)
• Provide strong scientific thinking, develop hypotheses and drive scientific learnings on projects/functional genomics platform
• Time split 70:30 between wet lab and office responsibilities

Job Requirements

Education and experience:
• Masters or PhD in applicable field with record of scientific achievement as evidenced by publications, presentations, or patents
• 3+ years of experience in application of functional genomics/CRISPR
• Experience of applying cellular and biochemical techniques for target identification, validation, genetic screening and evaluating the mechanism of action of novel molecular entities
• Experience in molecular biology approaches and advanced cell biology techniques (flow cytometry, gene and protein analysis, PCR, cloning, lentiviral library prep)
• Excellent communicator, with demonstrated ability to work across disciplines
• Ability to work independently and manage priorities and engage in a multidisciplinary environment

Preferred experience:
• CRISPR screening experience
• 1+ year experience in single cell technologies, with 10X expertise preferred
• Experience in differentiation and assay development with iPSCs
• Demonstrated experience in a matrixed drug discovery environment including working globally
(Job number: 3936272)
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