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Job: Applications Scientist, Foundation Medicine, Morrisville, NC

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General Information


Job title: Applications Scientist
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Job location: Morrisville, NC  27560 United States
Requisition code:
Date posted: 09/01/2017
Job category:Other
Employment type:Full time
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Job Description

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Foundation Medicine is leading a transformation in cancer care, where each patient's treatment is informed by a deep understanding of the molecular changes that contribute to their disease.

As a molecular information company, we are focused on fundamentally changing the way in which patients with cancer are treated. Our products provide more than information. They offer hope to patients, their families and friends, their physicians and caregivers.

As a member of the Foundation Medicine team you'll work with everyone fighting the disease—patients and their families, payers, physicians, drug developers—to raise awareness about this transformation in cancer care and Foundation Medicine's role to ensure we're delivering the tools and information they need to make an impact and drive access for patients everywhere.

Headquartered in the heart of Cambridge, MA, with an additional testing site located in Research Triangle Park, NC, we offer competitive salaries, generous benefits and with our rapid growth, ample career opportunities.

What makes Foundation Medicine so special?

The cancer treatment paradigm is evolving rapidly and we believe there is now widespread recognition that cancer is a disease of the genome, rather than a disease defined solely by its specific anatomical location in the body. Today, physicians increasingly use precision medicines to target cancers based on the specific genomic alterations driving their growth, but most currently available molecular diagnostic tests only reveal a few of the possible alterations. Foundation Medicine provides truly comprehensive molecular information products that can assess the broadest range of relevant genomic alterations from a patient's tumor and distill this complex molecular information into a concise and actionable format that reveals more treatment options for physicians and their patients.

We've seen the difference that our technology can make in the lives of patients, but there is still enormous potential to help even more people. In our drive to help transform the way in which patients with cancer are treated, we strive to improve every life we touch through our dedication to innovation, our commitment to people, and our passion for performance.

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Job Requirements

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Your impact on the patient journey:

As a member of the Laboratory Operations team, you will:

  • Provide onsite assay optimization and technical support for NGS-based clinical assays including hands-on training, delivering education-focused presentations, and writing detailed, accurate, and accessible experimental plans, SOPs, and reports summarizing assay and process performance
  • Troubleshoot technical problems and serve as a liaison with internal escalation teams as needed. Deliver timely and innovative solutions to address customer needs by working collaboratively with inter-disciplinary teams including R&D, Commercial, Clinical, QA, and BD groups.
  • Position requires ability to travel nationally (up to 10%)

Your expertise:

  • Demonstrated expertise in molecular biology and an in-depth understanding of the practices and principals of NGS, including DNA-seq and RNA-seq protocols, and various target-enrichment approaches (e.g. multiplex-PCR, hybrid selection).
  • Experience leading the systematic optimization and troubleshooting of complex molecular biology and NGS-based assays through integration of information related to the input sample, lab processes and data analysis pipeline
  • Validation and implementation of CLIA-certified tests including writing SOPs and validation plans/reports
  • Experience working with typical oncology specimens (e.g. FFPE, Blood, Bone Marrow)


  • Expertise working with robust protocols for high throughput laboratory automation
  • Utilization of Laboratory Information Management Systems (LIMS)
  • Experience with NGS analysis of liquid biopsies
  • Basic NGS data management and analysis (e.g. SAMtools, IGV/Picard, Python/Perl)
  • Prior experience in an FDA-regulated environment


  • M.S., or equivalent, in Molecular Biology, Biochemistry, Genetics, Biomedical Engineering is preferred
  • Minimum 3-4 years working in Industry and/or Academia
  • Demonstrated ability to clearly communicate scientific results in internal and external presentations and publications
  • Demonstrated ability to work independently and collaboratively in a dynamic, fast paced team environment

What you are:

Driven. You will be focused on the achievement of major alliance goals.
Solutions focused. Willing to bring creative problem-solving skills to challenges along the way.
Scientifically-oriented. You will enjoy learning and being involved in the content of our collaboration activities, and able to converse fluidly with internal and external team members on project goals and activities.
Intuitive. You will have a demonstrated ability to work in the “gray zone” and anticipate challenges before they arise.
Process-oriented, yet flexible. You will appreciate and be able to create and drive process, and at the same time recognize when rules are meant to be bent.
Ability to communicate clearly and concisely with all stakeholders.
A proven cross-functional leader. You will have demonstrated the ability to “influence without authority” and achieve objectives across complex projects and organizational structures.
Independent. You will be able to self-organize and operate effectively without significant day-to-day oversight, while staying tightly connected to key leaders and teams across the collaborations.

Apply Here

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